I have updated my blog to WordPress v2.8.1 which was just released. I did the auto upgrade option again which seems to have worked well. Even so, once again I had to edit the /wp-includes/vars.php file to force $is_apache to true (see below) since the SERVER_SOFTWARE variable comes back as WebServerX instead of Apache.

// Server detection
 
/**
 * Whether the server software is Apache or something else
 * @global bool $is_apache
 */
//$is_apache = ((strpos($_SERVER['SERVER_SOFTWARE'], 'Apache') !== false) || (strpos($_SERVER['SERVER_SOFTWARE'], 'LiteSpeed') !== false)) ? true : false;
$is_apache = true;
/**
 * Whether the server software is IIS or something else
 * @global bool $is_IIS
 */
$is_IIS = (strpos($_SERVER['SERVER_SOFTWARE'], 'Microsoft-IIS') !== false) ? true : false;

Other than the modification to vars.php which I have always had to do, the upgrade went smoothly.

Of course, I did perform a complete database and file backup before upgrading!