I have been using DestroyTwitter more and more and now that the latest 1.4.3beta supports themes, it will probably become my Twitter client of choice since I can now use it without going blind LOL. I really do not like applications with dark backgrounds. For my first theme (which is now compatible with version 1.4.4beta), I decided that I would match the colors used by TwitterFox as best I could:
Download theme: mrheadrick Blue
Enjoy! I may have to work on an Oklahoma State University theme next.